Big Bug Island is place where - thanks to the power emanated by the Shard of Osiris, the bugs grew into enormous size.

The leaders of the Camarilla arrived here to get the Shard of Osiris, which was held by The Queen. You Te hated the place since he is disgusted by bugs.

Yi Sai probably also visited the place, since he was seen making a report about it and abput what went on the island.